NCI-H209

Supplier:         CLS cell lines service, Germany

Cat no.:            300183

Amount:          1 cryovial

Organism:       Human

Tissue:            Lung

Disease:          Small cell carcinoma

Metastatic site: Bone marrow

Age:                 55 years

Gender:           Male

Ethnicity:        Caucasian

Morphology:   Epithelial-like

Growth Properties:  Suspension

Storage:           Below -150°C after arrival.

Description:    The NCI-H209 cell line is a renowned small cell lung cancer (SCLC) cell line derived in 1979 by A.F. Gazdar and his team from a bone marrow specimen of an untreated patient. Widely recognized for its distinctive features, this cell line uniquely grows as robust aggregates in suspension where only the clusters are viable. It’s crucial to note that the culture medium often comprises significant cell debris. A standout trait of the NCI-H209 line is its elevated expression of four key biochemical markers: neuron-specific enolase, brain isoenzyme of creatine kinase, L-DOPA decarboxylase, and bombesin-like immunoreactivity. Interestingly, this cell line doesn’t amplify C-myc DNA sequences and doesn’t exhibit any major DNA structural anomalies. Furthermore, it displays an unusual form of RB1 that remains unphosphorylated due to a codon 706 point mutation (Cys-> Phe). With its multifaceted characteristics, the NCI-H209 cell line stands as an invaluable resource for cancer research.

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