iMatrix-511 Stem Cell Culture Substrate

iMatrix-511 is a highly purified and refined laminin-511 E8 fragments, produced in CHO cells.

iMatrix-511 features make it an ideal matrix for pluripotent stem cell culture:

• Promotes greater stem cell adhesion than all other matrix proteins that have been tested
• Easy to use (liquid format)
• E8 fragments retain integrin binding specificity and capacity and display higher potency than natural Laminin-511
• Equivalent performance, but lower cost than the legacy iMatrix-511 product

Laminin is localized to the basement membrane and plays a key role in cell adhesion and proliferation. Laminin-511 (α5, β1 laminin) binds to integrin α6β1 to promote cell signaling. Laminin-511 provides an ideal matrix for the proliferation of a wide variety of cell types including stem and iPS cells.

iMatrix-511 is functionally equivalent to iMatrix-511 SILK (Cat. No. NP892-021). The only difference is the expression system used for bioproduction. The iMatrix-511 SILK product is produced in recombinant silkworm cocoon, while iMatrix-511  is produced in CHO-S cells. Both are E8 fragments that have been purified using the same processes.