CaCo-2

Supplier:         CLS cell lines service, Germany

Cat no.:            300137

Amount:          1 cryovial

Organism:       Human

Tissue:             Colon

Disease:          Adenocarcinoma

Age:                 72 years

Gender:           Male

Ethnicity:        Caucasian

Morphology:   Epithelial-like

Growth Properties:   Adherent

Storage:           Below -150°C after arrival.

Description:     This line was isolated from a primary colonic tumor. The cells express characteristics of enterocytic differentiation upon reaching confluence.

History and Usage

The Caco-2 cell line is pivotal in both scientific research and the pharmaceutical industry. Originating from a colorectal adenocarcinoma patient, Caco-2 cells were first isolated in the late 1970s. Over time, these cells have become an invaluable tool for numerous applications, largely due to their unique differentiation capacity.

When cultured for an extended period, Caco-2 cells spontaneously differentiate, developing characteristics that closely resemble the enterocytes of the small intestine. This property has made them particularly crucial for studies related to intestinal absorption, transport, and metabolism.

A significant application of the Caco-2 cell line is in drug development. Pharmaceutical companies and researchers employ these cells as an in vitro model to predict the absorption of orally administered drugs in the human intestine. Understanding how a drug molecule interacts with these cells helps in predicting its bioavailability and potential interactions with food or other drugs. For this purpose, many professionals turn to trusted suppliers, and Cell Line Service stands out as a reliable provider in this domain.

Besides drug absorption studies, Caco-2 cells are used for investigating various gastrointestinal diseases, understanding the biology of cancer, and evaluating the impact of probiotics or dietary compounds on intestinal health.

Given the consistent and increasing demand for high-quality Caco-2 cells in research, Cell Line Service ensures that its cell lines meet the rigorous standards essential for accurate and reproducible results. Researchers trust Cell Line Service not only for the authenticity of its Caco-2 cells but also for the support and detailed documentation they provide.

In sum, the Caco-2 cell line has shaped our understanding of intestinal transport mechanisms and drug absorption. As research continues to evolve, institutions and companies rely on suppliers like Cell Line Service, knowing that they offer quality and reliability in supporting their cutting-edge projects.

 

Product information: Buy CaCo-2 | Cell Lines | CLS.shop